Tocilizumab COVID-19 Study Shows Bias Against Observational Studies, Harvard Prof Says
Study showing Roche’s Actemra decreased mortality in COVID-19 patients in ICUs by almost 10% was initially rejected by journal editors and then ignored by guideline writers and regulators. FDA officials and industry reps discuss what needs to be done to advance use of real-world evidence from observational studies.
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The RECOVERY trial has found Actemra to help cut deaths and speed recovery – and UK doctors are not waiting for Roche to complete own studies.
Effort to replicate clinical trial results with real-world data could eventually allow for increased use in drug development.
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