Bristol Cements Lead In Immunotherapy
This article was originally published in The Pink Sheet Daily
FDA approval for Opdivo and Yervoy in combination and Opdivo as monotherapy for the treatment of all metastatic melanoma patients, regardless of BRAF mutation status, puts Bristol on equal footing with Merck in the indication, and positions it to take on the BRAF inhibitors.
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LAG-3 antibody shows improved PFS when combined with Opdivo in metastatic or inoperable melanoma. Bristol Myers Squibb still awaits overall survival data but could have its second dual checkpoint inhibitor pairing.
First adjuvant and combination approvals for immuno-oncology could help revive Yervoy in melanoma; Amgen’s oncolytic cancer vaccine emerges as new mechanism for select patients, with room to grow.
Cooperative group plans trial testing Yervoy vs. Zelboraf in first-line metastatic melanoma to help settle the issue of which therapy should come first in BRAF-mutation positive patients. New therapies on the way promise to further complicate decision-making.