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Immune Checkpoint Blockade: The New Big Idea In Cancer

Executive Summary

Biologics that target immune checkpoints co-opted by cancer resistance have been significantly de-risked by the success of Bristol’s immunotherapy Yervoy and the progress of its Phase III candidate nivolumab. With six companies now testing candidates in the clinic, the class promises to have a big impact on oncology over the next several years, with the possibility of a next-generation approval by 2015.

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