Doubts Linger Over Whether AVERROES Gives Any Advantage To Apixaban
Bristol-Myers Squibb Co./Pfizer Inc. have evidence in hand that their investigational anticoagulant apixaban is useful in patients who can’t take warfarin. But any marketing gains for apixaban in this niche could be limited by physician skepticism about the patient population, assumptions that other similar drugs will be just as good in that population, and the recent FDA approval of the rival oral drug Pradaxa.
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Contrary to expectations, Bristol-Myers Squibb will not file early for a narrow indication of the novel anticoagulant apixaban.
Bristol and Pfizer put an early end to the Phase III study successfully comparing their anticoagulant to aspirin, and the preliminary data bode well for further results due out mid-2011, but will they wait?