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Reading The Tea Leaves For PD-1 Family In New Hematology Data

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

Nivolumab investigator, ASH presidential symposium speaker and translational biologist Margaret Shipp explains in an interview why PD-1 blockade might be better in Hodgkin lymphoma than PD-L1 inhibition, and contemplates the future in other blood diseases.

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Biologics that target immune checkpoints co-opted by cancer resistance have been significantly de-risked by the success of Bristol’s immunotherapy Yervoy and the progress of its Phase III candidate nivolumab. With six companies now testing candidates in the clinic, the class promises to have a big impact on oncology over the next several years, with the possibility of a next-generation approval by 2015.

Rare Disease Roundtable: Dealing With Pricing Pressure

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Rare Disease Roundtable: How Rare Is Too Rare?

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