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Payback Time For Lilly? Erbitux Follow-on Succeeds In Squamous Lung Cancer Trial

This article was originally published in Pharmaceutical Approvals Monthly

Executive Summary

Lilly’s necitumumab – gained through the company’s ImClone acquisition – demonstrates an overall survival benefit in the SQUIRE study against first-line metastatic squamous NSCLC. Pleasantly surprised by the outcome, some analysts start to expect blockbuster sales.

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Melanoma Success Paves Way For Path Of Gold In Cancer Immunotherapy

Phase I data for immune checkpoint molecules in melanoma from Bristol, Roche and Merck were a major highlight of the ASCO 2013 annual meeting. Considering potential application in many cancers regardless of genetic mutations, some analysts are predicting billions in future sales.

Ramucirumab Becomes First Lilly ImClone Compound To Enjoy Phase III Success

The VEGF2-inhibitor demonstrated an overall survival benefit and prolonged progression-free survival in second-line gastric cancer, Lilly said. The big pharma acquired ramucirumab through its $6.5 billion purchase of ImClone Systems in 2008.

Blood Clot Risk Causes Lilly, Bristol To Halt Enrollment In Erbitux Follow-On Trial

Safety concern occurs about one year after the two companies resolved rights dispute over antibody arising from Lilly/ImClone merger.

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