Supplement bioavailability
This article was originally published in The Tan Sheet
Executive Summary
Multiple ingredients in dietary supplements "can have a range of biopharmaceutical characteristics" that will have a profound effect on oral absorption rates, Jae Seung Kum, et al., University of Michigan, report at AAPS meeting. Researchers measured the permeability and solubility of select supplement markers, such as hyperforin (St. John's wort), quercetin (ginkgo biloba) and phenolate (echinacea), compared to highly permeable compounds metoprolol and carbamazapine. "The permeabilities of many of the marker compounds were higher" than the two control compounds, Kum et al. state, suggesting that in order to ascertain bioequivalence for supplements, dissolution standards must first be established