GlaxoSmithKline Zyban
Executive Summary
A modified dosing schedule for bupropion is implemented by the U.K. Medicines Control Agency May 30 following reports of seizures. Over 419,000 patients have been treated in the U.K. and 126 seizures have been reported. In about 50% of the cases, patients had predisposing factors for seizure. The MCA is recommending that Zyban should be dosed at 150 mg once daily for the first six days of treatment before switching to twice daily on day seven. In the U.S., patients are switched to twice daily dosing on day four