Taxol/cisplatin three-hour therapy causes higher rate of peripheral neuropathy -- Gynecologic Oncology.

Executive Summary

TAXOL/CISPLATIN THREE-HOUR COMBO THERAPY INCREASES PERIPHERAL NERVE DAMAGE incidence compared to the regimen given over 24 hours, according to results of a study published in the August issue of Gynecologic Oncology. The 38-patient study was conducted at the Cleveland Clinic Cancer Center in Ohio and involved 20 ovarian, six primary peritoneal and 12 endometrial malignancy patients who were administered 170 cycles of 135 mg/m2 or 175 mg/m2 paclitaxel (Bristol-Myers Squibb's Taxol) over three hours immediately followed by 75 mg/m2 cisplatin delivered over 30 minutes.