Searle's Maxaquin

Executive Summary

Company's once-daily oral quinolone antimicrobial drug lomefloxacin will be subject of a March 31 joint meeting of FDA's Anti-Infective and Dermatologic Drugs Advisory Committees. "Recent reports of phototoxicity thought to be associated with the use of lomefloxacin" and a recent Roche-sponsored animal photocarcinogenicity study in which Maxaquin "appears to act as a dermal tumor promoter" will be discussed as to their relevance to humans, regulatory options for the drug and options for information dissemination. Maxaquin was approved Feb. 21, 1992 ("The Pink Sheet" March 2, 1992, T&G-1). Meeting begins at 8:30 a.m. at the Holiday Inn, Silver Spring, Md.